Transdiagnostic neurocognitive deficits in patients with type 2 diabetes mellitus, major depressive disorder, bipolar disorder, and schizophrenia: A 1-year follow-up study

Patricia Correa-Ghisays; Joan Vicent Sánchez-Ortí; Vicent Balanzá-Martínez; Gabriel Selva-Vera; Joan Vila-Francés; Rafael Magdalena-Benedito; Victor M Victor; Irene Escribano-López; Antonio Hernández-Mijares; Juliana Vivas-Lalinde; Constanza San-Martín; Benedicto Crespo-Facorro; Rafael Tabarés-Seisdedos

doi:10.1016/j.jad.2021.12.074

Transdiagnostic neurocognitive deficits in patients with type 2 diabetes mellitus, major depressive disorder, bipolar disorder, and schizophrenia: A 1-year follow-up study

J Affect Disord. 2022 Mar 1:300:99-108. doi: 10.1016/j.jad.2021.12.074. Epub 2021 Dec 26.

Authors

Affiliations

¹ Centro Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Madrid 28029, Spain; TMAP - Unidad de Evaluación en Autonomía Personal, Dependencia y Trastornos Mentales Graves, University of Valencia, Valencia 46010, Spain; INCLIVA - Health Research Institute, Valencia 46010, Spain; Faculty of Psychology, University of Valencia, Valencia 46010, Spain; Teaching Unit of Psychiatry and Psychological Medicine, Department of Medicine, University of Valencia, Blasco-Ibáñez 17, Valencia 46010, Spain.
² TMAP - Unidad de Evaluación en Autonomía Personal, Dependencia y Trastornos Mentales Graves, University of Valencia, Valencia 46010, Spain; INCLIVA - Health Research Institute, Valencia 46010, Spain; Faculty of Psychology, University of Valencia, Valencia 46010, Spain.
³ Centro Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Madrid 28029, Spain; TMAP - Unidad de Evaluación en Autonomía Personal, Dependencia y Trastornos Mentales Graves, University of Valencia, Valencia 46010, Spain; INCLIVA - Health Research Institute, Valencia 46010, Spain; Teaching Unit of Psychiatry and Psychological Medicine, Department of Medicine, University of Valencia, Blasco-Ibáñez 17, Valencia 46010, Spain; Unitat de Salut Mental de Catarroja, Valencia 46470, Spain.
⁴ Centro Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Madrid 28029, Spain; TMAP - Unidad de Evaluación en Autonomía Personal, Dependencia y Trastornos Mentales Graves, University of Valencia, Valencia 46010, Spain; INCLIVA - Health Research Institute, Valencia 46010, Spain; Teaching Unit of Psychiatry and Psychological Medicine, Department of Medicine, University of Valencia, Blasco-Ibáñez 17, Valencia 46010, Spain.
⁵ IDAL - Intelligent Data Analysis Laboratory, University of Valencia, Valencia 46100, Spain.
⁶ Service of Endocrinology and Nutrition, University Hospital Doctor Peset, Foundation for the Promotion of Health and Biomedical Research in the Valencian Region (FISABIO), Valencia 46017, Spain; Department of Physiology, University of Valencia, Valencia 46010, Spain.
⁷ Service of Endocrinology and Nutrition, University Hospital Doctor Peset, Foundation for the Promotion of Health and Biomedical Research in the Valencian Region (FISABIO), Valencia 46017, Spain.
⁸ Service of Endocrinology and Nutrition, University Hospital Doctor Peset, Foundation for the Promotion of Health and Biomedical Research in the Valencian Region (FISABIO), Valencia 46017, Spain; Department of Medicine, University of Valencia, Valencia 46010, Spain.
⁹ Departament of Psychiatry, Mental Health Service, Valencia, Manises 46940, Spain.
¹⁰ TMAP - Unidad de Evaluación en Autonomía Personal, Dependencia y Trastornos Mentales Graves, University of Valencia, Valencia 46010, Spain; Departament of Physioterapy, University of Valencia, Valencia 46010, Spain.
¹¹ Centro Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Madrid 28029, Spain; Hospital Universitario Virgen del Roció-IBIS- University of Sevilla, Sevilla, Spain.
¹² Centro Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Madrid 28029, Spain; TMAP - Unidad de Evaluación en Autonomía Personal, Dependencia y Trastornos Mentales Graves, University of Valencia, Valencia 46010, Spain; INCLIVA - Health Research Institute, Valencia 46010, Spain; Teaching Unit of Psychiatry and Psychological Medicine, Department of Medicine, University of Valencia, Blasco-Ibáñez 17, Valencia 46010, Spain. Electronic address: Rafael.Tabares@uv.es.

PMID: 34965401
DOI: 10.1016/j.jad.2021.12.074

Abstract

Background: Neurocognition impairments are critical factors in patients with major depressive disorder (MDD), bipolar disorder (BD), and schizophrenia (SZ), and also in those with somatic diseases such as type 2 diabetes mellitus (T2DM). Intriguingly, these severe mental illnesses are associated with an increased co-occurrence of diabetes (direct comorbidity). This study sought to investigate the neurocognition and social functioning across T2DM, MDD, BD, and SZ using a transdiagnostic and longitudinal approach.

Methods: A total of 165 participants, including 30 with SZ, 42 with BD, 35 with MDD, 30 with T2DM, and 28 healthy controls (HC), were assessed twice at a 1-year interval using a comprehensive, integrated test battery on neuropsychological and social functioning.

Results: Common neurocognitive impairments in somatic and psychiatric disorders were identified, including deficits in short-term memory and cognitive reserve (p < 0.01, η²p=0.08-0.31). Social functioning impairments were observed in almost all the disorders (p < 0.0001; η²p=0.29-0.49). Transdiagnostic deficits remained stable across the 1-year follow-up (p < 0.001; η²p=0.13-0.43) and could accurately differentiate individuals with somatic and psychiatric disorders (χ² = 48.0, p < 0.0001).

Limitations: The initial sample size was small, and high experimental mortality was observed after follow-up for one year.

Conclusions: This longitudinal study provides evidence of some possible overlap in neurocognition deficits across somatic and psychiatric diagnostic categories, such as T2DM, MDD, BD, and SZ, which have high comorbidity. This overlap may be a result of shared genetic and environmental etiological factors. The findings open promising avenues for research on transdiagnostic phenotypes of neurocognition in these disorders, in addition to their biological bases.

Keywords: Bipolar disorder; Major depressive disorder; Schizophrenia; Transdiagnostic neurocognitive deficits; Type 2 diabetes mellitus.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Bipolar Disorder* / complications
Bipolar Disorder* / diagnosis
Bipolar Disorder* / epidemiology
Depressive Disorder, Major* / complications
Depressive Disorder, Major* / diagnosis
Depressive Disorder, Major* / epidemiology
Diabetes Mellitus, Type 2* / complications
Follow-Up Studies
Humans
Longitudinal Studies
Schizophrenia* / complications
Schizophrenia* / diagnosis