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Review
. 2023 Feb;290(3):649-668.
doi: 10.1111/febs.16337. Epub 2022 Feb 7.

Targeting the molecular & cellular pillars of human aging with exercise

Jorming Goh  1   2   3 , Esther Wong  1   2   3 , Janjira Soh  3   4 , Andrea Britta Maier  1   3   5   6   7 , Brian Keith Kennedy  1   2   3   4
Affiliations
Free article
Review

Targeting the molecular & cellular pillars of human aging with exercise

Jorming Goh et al. FEBS J. 2023 Feb.
Free article

Abstract

Biological aging is the main driver of age-associated chronic diseases. In 2014, the United States National Institute of Aging (NIA) sponsored a meeting between several investigators in the field of aging biology, who identified seven biological pillars of aging and a consensus review, "Geroscience: Linking Aging to Chronic Disease," was published. The pillars of aging demonstrated the conservation of aging pathways in diverse model organisms and thus represent a useful framework with which to study human aging. In this present review, we revisit the seven pillars of aging from the perspective of exercise and discuss how regular physical exercise can modulate these pillars to stave off age-related chronic diseases and maintain functional capacity.

Keywords: aging; disruption in proteostasis; dysregulated stress response; epigenetic drift; inflammaging; macromolecular damage; metabolic dysregulation; stem cell exhaustion.

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