What Function Do Platelets Play in Inflammation and Bacterial and Viral Infections?

Front Immunol. 2021 Dec 14:12:770436. doi: 10.3389/fimmu.2021.770436. eCollection 2021.

Abstract

The article presents the function of platelets in inflammation as well as in bacterial and viral infections, which are the result of their reaction with the endovascular environment, including cells of damaged vascular endothelium and cells of the immune system. This role of platelets is conditioned by biologically active substances present in their granules and in their specific structures - EV (extracellular vesicles).

Keywords: bacterial infection; immunity; inflammation; platelets; viral infection.

Publication types

  • Review

MeSH terms

  • Bacterial Infections / immunology*
  • Bacterial Infections / microbiology
  • Blood Platelets / immunology*
  • Blood Platelets / metabolism
  • Cytokines / immunology
  • Cytokines / metabolism
  • Endothelium, Vascular / immunology
  • Endothelium, Vascular / metabolism
  • Extracellular Vesicles / immunology*
  • Humans
  • Immune System / immunology*
  • Immune System / microbiology
  • Immune System / virology
  • Inflammation / immunology*
  • Inflammation / metabolism
  • Inflammation Mediators / immunology
  • Inflammation Mediators / metabolism
  • Models, Immunological
  • Signal Transduction / immunology
  • Virus Diseases / immunology*
  • Virus Diseases / virology

Substances

  • Cytokines
  • Inflammation Mediators