Malignant lymphoma of mucosa-associated lymphoid tissue

Histopathology. 1987 May;11(5):445-62. doi: 10.1111/j.1365-2559.1987.tb02654.x.


Lymphomas of the gastrointestinal tract, salivary glands, lung and thyroid are grouped together as tumours arising in mucosa-associated lymphoid tissue. The great majority of them are of B-cell origin but distinctive T-cell lymphomas are also recognized in the gastrointestinal tract. These lymphomas tend to remain localized for prolonged periods but, whereas the B-cell group respond favourably to local therapy, the T-cell group are associated with severe morbidity and their overall prognosis is extremely poor. Accepted histological classifications of non-Hodgkin's lymphomas are difficult to apply to these tumours. In this paper their morphological features are reviewed; recent findings based on immunohistochemistry and DNA analysis are presented; and the biological behaviour of these tumours is discussed insofar as they offer insight into mucosal immunological mechanisms.

MeSH terms

  • B-Lymphocytes / pathology
  • Humans
  • Immunochemistry
  • Lymphoid Tissue / pathology*
  • Lymphoma / immunology
  • Lymphoma / pathology*
  • Mucous Membrane / pathology
  • Stomach Neoplasms / immunology
  • Stomach Neoplasms / pathology
  • T-Lymphocytes / pathology