Bacterial cellulose-based biomaterials: From fabrication to application

Carbohydr Polym. 2022 Feb 15:278:118995. doi: 10.1016/j.carbpol.2021.118995. Epub 2021 Dec 10.


Driven by its excellent physical and chemical properties, BC (bacterial cellulose) has achieved significant progress in the last decade, rendering with many novel applications. Due to its resemblance to the structure of extracellular matrix, BC-based biomaterials have been widely explored for biomedical applications such as tissue engineering and drug delivery. The recent advances in nanotechnology endow further modifications on BC and generate BC-based composites for different applications. This article presents a review on the research advancement on BC-based biomaterials from fabrication methods to biomedical applications, including wound dressing, artificial skin, vascular tissue engineering, bone tissue regeneration, drug delivery, and other applications. The preparation of these materials and their potential applications are reviewed and summarized. Important factors for the applications of BC in biomedical applications including degradation and pore structure characteristic are discussed in detail. Finally, the challenges in future development and potential advances of these materials are also discussed.

Keywords: Application; Bacterial cellulose; Biodegradation; Biomaterials; Fabrication; Tissue engineering.

Publication types

  • Review

MeSH terms

  • Biocompatible Materials / chemistry*
  • Carbohydrate Conformation
  • Cellulose / chemistry*
  • Drug Delivery Systems*
  • Gram-Negative Bacteria / chemistry*
  • Tissue Engineering*


  • Biocompatible Materials
  • Cellulose