A Normative Brain MRI Database of Neurotypical Participants from 5 to 90 Years of Age

Can J Neurol Sci. 2023 Mar;50(2):282-286. doi: 10.1017/cjn.2021.513. Epub 2022 Jan 3.

Abstract

Brain magnetic resonance imaging (MRI) studies of clinical populations often require comparison to a normative 'control' cohort, usually of similar age/sex, scanned with the same protocol. The goal here was to create a normative brain MRI database of common quantitative methods to be used in comparisons with a variety of neurological disorders across the lifespan. 378 neurotypical controls (aged 5-90 years; median 31 years; 216 females, 162 males) completed brain MRI, cognitive testing, clinical assessment, and a demographics questionnaire. In addition, this large normative sample will yield novel insight into healthy brain development and aging.

Keywords: Aging; Brain; Development; MRI; Normative database.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Aging* / pathology
  • Brain* / diagnostic imaging
  • Brain* / pathology
  • Child
  • Child, Preschool
  • Female
  • Humans
  • Magnetic Resonance Imaging / methods
  • Male
  • Middle Aged
  • Young Adult