Vitreoscilla filiformis Extract for Topical Skin Care: A Review

Front Cell Infect Microbiol. 2021 Dec 16:11:747663. doi: 10.3389/fcimb.2021.747663. eCollection 2021.


The term probiotic has been defined by experts as live microorganisms, which when administered in adequate amounts, confer a health benefit on the host. Probiotics are, thus, by definition, live microorganisms, and the viability of probiotics is a prerequisite for certain benefits, such as the release of metabolites at the site or adhesion properties, for example. However, some semi-active or non-replicative bacterial preparations may retain a similar activity to the live forms. On cosmetic, lysates or fractions are generally used. Topically applied Vitreoscilla filiformis extract has shown to have some similar biological activity of probiotics in the gut, for example, regulating immunity by optimisation of regulatory cell function, protecting against infection, and helping skin barrier function for better recovery and resistance. Due to their mode of action and efficacy, V. filiformis extract (lysate including membrane and cytosol) may be considered as non-replicative probiotic fractions, and this review article presents all its properties.

Keywords: Vitreoscilla; immunity; microbiome; skin barrier; skin defences.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Plant Extracts
  • Probiotics*
  • Skin Care
  • Vitreoscilla*


  • Plant Extracts

Supplementary concepts

  • Vitreoscilla filiformis