Vedolizumab Therapy in Refractory Enteropathy Associated With CVID

ACG Case Rep J. 2021 Dec 28;9(1):e00721. doi: 10.14309/crj.0000000000000721. eCollection 2022 Jan.


Common variable immunodeficiency (CVID) is a disorder of typically adult-onset hypogammaglobulinemia in the absence of other known causes. Noninfectious gastrointestinal tract manifestations are common, and a subset of patients with CVID present with a severe enteropathy manifesting as severe malabsorption, weight loss, and diarrhea. A 63-year-old man presented with CVID and severe enteropathy who failed to improve with cytomegalovirus therapy, multiple empiric therapies, and corticosteroids. Vedolizumab infusions were initiated with a dramatic, rapid, and durable complete clinical response.

Publication types

  • Case Reports