Sporadic Burkitt Lymphoma Involving the Orbit - A Report of Two Cases and Review of Literature

Orbit. 2023 Aug;42(4):426-430. doi: 10.1080/01676830.2021.2020849. Epub 2022 Jan 3.

Abstract

Burkitt lymphoma (BL) is an aggressive, rapidly growing B-cell non-Hodgkin lymphoma found predominantly in children and has three clinical subtypes. The sporadic subtype, seen in non-endemic areas, typically presents as an abdominal mass. Primary orbital involvement is rarely reported. We report two cases of sporadic orbital BL manifesting as unilateral rapidly progressive proptosis with orbit being the initial site of presentation. Following an incision biopsy, BL was confirmed on histopathology and immunohistochemistry. Both patients demonstrated a remarkable improvement with systemic chemotherapy. Burkitt lymphomas grow rapidly with the potential for vision loss. Albeit rare, clinicians should be aware of this entity as timely diagnosis and initiation with chemotherapy display a dramatic response.

Keywords: B- cell tumor; Burkitt lymphoma; non – Hodgkin lymphoma.

Publication types

  • Review
  • Case Reports

MeSH terms

  • Biopsy
  • Burkitt Lymphoma* / diagnostic imaging
  • Burkitt Lymphoma* / drug therapy
  • Child
  • Exophthalmos* / diagnosis
  • Humans
  • Immunohistochemistry
  • Orbit / pathology