Review on design strategies and considerations of polysaccharide-based smart drug delivery systems for cancer therapy

Qingye Meng; Shuangling Zhong; Lifeng Xu; Jingfei Wang; Zhenqian Zhang; Yan Gao; Xuejun Cui

doi:10.1016/j.carbpol.2021.119013

Review on design strategies and considerations of polysaccharide-based smart drug delivery systems for cancer therapy

Carbohydr Polym. 2022 Mar 1:279:119013. doi: 10.1016/j.carbpol.2021.119013. Epub 2021 Dec 15.

Authors

Qingye Meng¹, Shuangling Zhong², Lifeng Xu¹, Jingfei Wang¹, Zhenqian Zhang¹, Yan Gao³, Xuejun Cui⁴

Affiliations

¹ College of Chemistry, Jilin University, Changchun 130012, PR China.
² College of Resources and Environment, Jilin Agricultural University, Changchun 130118, PR China.
³ College of Chemistry, Jilin University, Changchun 130012, PR China; State Key Laboratory of Supramolecular Structure and Materials, Jilin University, Changchun 130012, PR China; Weihai Institute for Bionics-Jilin University, Weihai 264400, PR China. Electronic address: gaoy@jlu.edu.cn.
⁴ College of Chemistry, Jilin University, Changchun 130012, PR China; Weihai Institute for Bionics-Jilin University, Weihai 264400, PR China. Electronic address: cui_xj@jlu.edu.cn.

PMID: 34980356
DOI: 10.1016/j.carbpol.2021.119013

Abstract

The unique natural advantages of polysaccharide materials have attracted attention in biomedical applications. The abundant modifiable functional groups on the polysaccharide materials surface can facilitate the synthesis of various multifunctional drug delivery carriers. Especially in tumor therapy, the designs of polysaccharide-based drug delivery carriers are diverse. Therefore, this review summarized several latest types of polysaccharide-based drug carriers designs, and focused on the latest design strategies and considerations of drug carriers with polysaccharides as the main structure. It is expected to provide some design ideas and inspiration for subsequent polysaccharide-based drug delivery systems.

Keywords: Cancer therapy; Drug delivery system; Polysaccharide.

Publication types

Review

MeSH terms

Animals
Antineoplastic Agents / administration & dosage
Antineoplastic Agents / chemistry*
Drug Carriers / administration & dosage
Drug Carriers / chemistry*
Drug Carriers / classification
Drug Design
Humans
Neoplasms / drug therapy
Polysaccharides / administration & dosage
Polysaccharides / chemistry*

Substances

Antineoplastic Agents
Drug Carriers
Polysaccharides