Targeting p21 for diabetes: Another choice of senotherapy

Cell Metab. 2022 Jan 4;34(1):5-7. doi: 10.1016/j.cmet.2021.12.008.


Senotherapy, the elimination of senescent cells, is a cutting-edge treatment for aging-related and lifestyle diseases. In this issue of Cell Metabolism, Wang et al. report that p21Cip1 highly expressing cells, which represent a senescent cell population, occur in the adipose tissue during obesity. Targeting them genetically or pharmacologically attenuates insulin resistance, suggesting a possible therapeutic approach to treat the metabolic complications of obesity.

Publication types

  • Comment

MeSH terms

  • Adipose Tissue
  • Aging
  • Cellular Senescence
  • Diabetes Mellitus*
  • Humans
  • Insulin Resistance*