Ketofol for Procedural Sedation and Analgesia in the Pediatric Population

Pediatr Emerg Care. 2022 Jan 1;38(1):28-33. doi: 10.1097/PEC.0000000000002599.


The combination of ketamine and propofol, commonly referred to as ketofol, is sometimes used for procedural sedation and analgesia in the pediatric emergency department. This article reviews the pharmacology, dosing, and indications, as well as adverse effects and contraindications of ketamine, propofol, and ketofol.

Publication types

  • Review

MeSH terms

  • Analgesia*
  • Child
  • Conscious Sedation
  • Emergency Service, Hospital
  • Humans
  • Hypnotics and Sedatives / adverse effects
  • Ketamine* / adverse effects
  • Pain Management
  • Propofol* / adverse effects


  • Hypnotics and Sedatives
  • Ketamine
  • Propofol