Large cell transformation of subclinical small lymphocytic leukemia/lymphoma: a variant of Richter's syndrome

Hematol Oncol. Jul-Sep 1987;5(3):167-74. doi: 10.1002/hon.2900050303.


The authors report three cases of diffuse aggressive non-Hodgkin's lymphomas (large cell, two; mixed small and large cell, one) arising in association with clinically silent small lymphocytic proliferations involving bone marrow, and lymph nodes. Immunologic marker studies suggested origin from a common B cell clone in two cases; in one case the large cell lymphoma lacked detectable surface markers. Some cases of diffuse aggressive lymphomas of adults may arise by large cell transformation of clinically silent small lymphocytic proliferations, a process akin to Richter's syndrome.

MeSH terms

  • Aged
  • B-Lymphocytes
  • Biomarkers, Tumor / analysis
  • Bone Marrow / pathology
  • Cell Transformation, Neoplastic
  • Female
  • Humans
  • Leukemia, Lymphoid / pathology*
  • Lymph Nodes / pathology
  • Lymphoma, Non-Hodgkin / pathology*
  • Male


  • Biomarkers, Tumor