How and where to expect endosalpingiosis intraoperatively

Fertil Steril. 2022 Feb;117(2):461-462. doi: 10.1016/j.fertnstert.2021.11.016. Epub 2022 Jan 2.


Objective: To describe the anatomical distribution and intraoperative morphology of endosalpingiosis.

Design: Retrospective observational video study.

Setting: Data and intraoperative videos were reviewed by two independent reviewers at one referral center. The study was approved by the local ethics committee.

Patient(s): A total of 77 patients with histologically proven endosalpingiosis from 2007-2020.

Intervention(s): None.

Main outcome measure(s): The primary endpoints were anatomical distribution and macroscopic phenotype. The secondary endpoints were demographic and clinical characteristics as well as associated diseases.

Result(s): Of the 77 patients with endosalpingiosis, the mean age was 40.2 years (standard deviation, 16.4 years), mean body mass index 24.1 kg/m2 (standard deviation, 5.7 kg/m2), 59.7% (n = 46) were nulligravide, 70.1% (n = 54) nulliparous, 22.1% (n = 17) suffered of infertility, and 53.2% (n = 41) had at least one previous abdominal or vaginal surgery. Endometriosis was associated in 53.2 % (n = 41) and malignancies in 28.6% (n = 22, 7 endometrial cancers, 1 uterine carcinosarcoma, 8 borderline ovarian tumors, 5 epithelial ovarian cancers, and 1 yolk sac tumor of the ovary). Anatomic distribution and varying intraoperative phenotypes were demonstrated in the video presentation.

Conclusion(s): In the majority of this population, endosalpingiosis was located in the pelvis. The higher prevalence of specific gynecologic tumors is consistent with previous results. In phenotype, most lesions appear to be less spectacular than prominent in the literature. For further studies on the relevance as a risk factor for malignancy and consequently clinical recommendations, sound knowledge about endosalpingiosis of laparoscopists as initial diagnosticians is crucial.

Keywords: Endosalpingiosis; borderline ovarian tumor; endometrial cancer; endoscopy; epithelial ovarian cancer; laparoscopy; müllerianosis.

Publication types

  • Observational Study
  • Video-Audio Media

MeSH terms

  • Adult
  • Endometrial Neoplasms / pathology
  • Endometrial Neoplasms / surgery*
  • Endometriosis / pathology
  • Endometriosis / surgery*
  • Fallopian Tube Diseases / pathology
  • Fallopian Tube Diseases / surgery*
  • Female
  • Gynecologic Surgical Procedures*
  • Humans
  • Middle Aged
  • Ovarian Neoplasms / pathology
  • Ovarian Neoplasms / surgery*
  • Phenotype
  • Retrospective Studies