Histocompatibility studies in pre-eclampsia

Tissue Antigens. 1987 May;29(5):232-6. doi: 10.1111/j.1399-0039.1987.tb01582.x.


Full HLA-A, B and DR types were obtained for 22 families (mothers, fathers and neonates) associated with severe (proteinuric) pre-eclampsia, 21 families associated with mild pre-eclampsia, and 132 families associated with normal pregnancies. There was an increased frequency of DR4 (relative risk 3.6: p less than 0.003, uncorrected) in both neonates and mothers of the severe pre-eclampsia families when compared to the normotensive controls. There were no significant differences between either pre-eclampsia group and controls in HLA antigen homozygosity, HLA antigen sharing or in lymphocytotoxin production.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Female
  • Gene Frequency
  • HLA Antigens / genetics
  • HLA-DR Antigens / genetics
  • HLA-DR4 Antigen
  • Histocompatibility*
  • Humans
  • Infant, Newborn
  • Male
  • Maternal-Fetal Exchange
  • Pre-Eclampsia / etiology
  • Pre-Eclampsia / genetics
  • Pre-Eclampsia / immunology*
  • Pregnancy


  • HLA Antigens
  • HLA-DR Antigens
  • HLA-DR4 Antigen