The term "maskne" has been coined during the ongoing COVID-19 pandemic, designating acne associated with prolonged protective mask-wearing. Maskne is a variant of acne mechanica caused by mask-induced mechanical injury (pressure, friction, and rubbing) and occlusion. The additional factors influencing the onset of maskne include genetics, environmental factors, duration of mask-wearing, the type of mask, and previous facial skin disease. The prevalence of maskne is increasing since masks are the most commonly used personal protective equipment in the general population. Furthermore, wearing masks in public tends to become the "new normal" even in the post-pandemic period. Hence, the problem of maskne could become even more significant. This review aims to provide a comprehensive view of current knowledge on prevalence, pathogenesis, prevention, and treatment of maskne.