Progress on the Function and Application of Thymosin β4

Yuan Xing; Yumeng Ye; Hongyan Zuo; Yang Li

doi:10.3389/fendo.2021.767785

Progress on the Function and Application of Thymosin β4

Front Endocrinol (Lausanne). 2021 Dec 21:12:767785. doi: 10.3389/fendo.2021.767785. eCollection 2021.

Authors

Yuan Xing^{1

2}, Yumeng Ye¹, Hongyan Zuo¹, Yang Li^{1

3}

Affiliations

¹ Department of Experimental Pathology, Beijing Institute of Radiation Medicine, Beijing, China.
² Department of Pharmacy, The First Affiliated Hospital of Hebei North University, Zhangjiakou, China.
³ Academy of Life Sciences, Anhui Medical University, Hefei City, China.

Abstract

Thymosin β4 (Tβ4) is a multifunctional and widely distributed peptide that plays a pivotal role in several physiological and pathological processes in the body, namely, increasing angiogenesis and proliferation and inhibiting apoptosis and inflammation. Moreover, Tβ4 is effectively utilized for several indications in animal experiments or clinical trials, such as myocardial infarction and myocardial ischemia-reperfusion injury, xerophthalmia, liver and renal fibrosis, ulcerative colitis and colon cancer, and skin trauma. Recent studies have reported the potential application of Tβ4 and its underlying mechanisms. The present study reveals the progress regarding functions and applications of Tβ4.

Keywords: angiogenesis; apoptosis; inflammation; signaling pathway; thymosin β4; tissue repair.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Apoptosis / drug effects
Apoptosis / physiology*
Humans
Inflammation / metabolism*
Signal Transduction / drug effects
Signal Transduction / physiology*
Thymosin / pharmacology
Thymosin / physiology*

Substances

thymosin beta(4)
Thymosin