Clinical Epidemiology, Risk Factors, and Control Strategies of Klebsiella pneumoniae Infection

De Chang; Lokesh Sharma; Charles S Dela Cruz; Dong Zhang

doi:10.3389/fmicb.2021.750662

Clinical Epidemiology, Risk Factors, and Control Strategies of Klebsiella pneumoniae Infection

Front Microbiol. 2021 Dec 22:12:750662. doi: 10.3389/fmicb.2021.750662. eCollection 2021.

Authors

De Chang^{1

2}, Lokesh Sharma³, Charles S Dela Cruz³, Dong Zhang^{4

5}

Affiliations

¹ Department of Pulmonary and Critical Care Medicine, The Third Medical Center of Chinese PLA General Hospital, Beijing, China.
² College of Pulmonary and Critical Care Medicine, Chinese PLA General Hospital, Beijing, China.
³ Section of Pulmonary and Critical Care and Sleep Medicine, Department of Medicine, Yale University School of Medicine, New Haven, CT, United States.
⁴ Department of Oncology, The Second Medical Center of Chinese PLA General Hospital, Beijing, China.
⁵ College of Tuberculosis Medicine, Chinese PLA General Hospital, Beijing, China.

Abstract

Klebsiella species cause infections at multiple sites, including lung, urinary tract, bloodstream, wound or surgical site, and brain. These infections are more likely to occur in people with preexisting health conditions. Klebsiella pneumoniae (K. pneumoniae) has emerged as a major pathogen of international concern due to the increasing incidences of hypervirulent and carbapenem-resistant strains. It is imperative to understand risk factors, prevention strategies, and therapeutic avenues to treat multidrug-resistant Klebsiella infections. Here, we highlight the epidemiology, risk factors, and control strategies against K. pneumoniae infections to highlight the grave risk posed by this pathogen and currently available options to treat Klebsiella-associated diseases.

Keywords: CRKP; Klebsiella pneumoniae; clinical epidemiology; control strategies; hvKp; risk factors.

Publication types

Review