Bio-fabrication of Selenium Nanoparticles Using Baker's Yeast Extract and Its Antimicrobial Efficacy on Food Borne Pathogens

Appl Biochem Biotechnol. 2022 May;194(5):1898-1910. doi: 10.1007/s12010-022-03809-8. Epub 2022 Jan 7.


In the current study, selenium nanoparticles (SeNPs) were biosynthesized via extract of baker's yeast (Saccharomyces cerevisiae) for a green, economic, and eco-friendly strategy. The biosynthesized SeNPs were characterized using UV-vis, XRD, FTIR, DLS, and TEM. The particulates showed a spherical morphology with diameters between 4 and 51 nm; FTIR studies on NPs show functional groups corresponding to metabolites (proteins), which reduces and stabilizes the nanoparticle. Antimicrobial efficacy of biosynthesized SeNPs against food borne pathogens was assessed. SeNPs showed promising antimicrobial action against food borne pathogens (Escherichia coli, Staphylococcus aureus, Aspergillus fumigatus, and Aspergillus niger) with a minimal inhibitory concentration (MIC) of 62.5, 125, 250, and 500 µg/mL against Staphylococcus aureus, Escherichia coli, Aspergillus fumigatus, and Aspergillus niger, respectively. In conclusion, the biosynthesized SeNPs using extract of baker's yeast are promising as a safe antimicrobial agent against food pathogens. Hence, the biosynthesized SeNPs using baker's yeast extract exhibit antimicrobial activities and could be a useful efficacious antimicrobial agent in the preservation of food and medical field.

Keywords: Antimicrobial; Characterization; Food borne pathogens; Saccharomyces cerevisiae; Selenium nanoparticles.

MeSH terms

  • Anti-Bacterial Agents / pharmacology
  • Anti-Infective Agents* / pharmacology
  • Escherichia coli
  • Metal Nanoparticles*
  • Nanoparticles*
  • Saccharomyces cerevisiae
  • Selenium*


  • Anti-Bacterial Agents
  • Anti-Infective Agents
  • Selenium