How CEP164 ciliopathy mutations impair ciliogenesis

Ciaran G Morrison

doi:10.1016/j.str.2021.12.007

How CEP164 ciliopathy mutations impair ciliogenesis

Structure. 2022 Jan 6;30(1):4-5. doi: 10.1016/j.str.2021.12.007.

Author

Ciaran G Morrison¹

Affiliation

¹ Centre for Chromosome Biology, National University of Ireland Galway, Dangan H91 W2TY, Galway, Ireland. Electronic address: ciaran.morrison@nuigalway.ie.

PMID: 34995479
DOI: 10.1016/j.str.2021.12.007

Abstract

CEP164 recruits TTBK2 to the distal end of centrioles to allow primary cilium formation. In this issue of Structure, Rosa e Silva et al. (2022) present co-crystallized structures that show the molecular basis of this recruitment and define how ciliopathy mutations in CEP164 disrupt the CEP164-TTBK2 complex.

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MeSH terms

Centrioles / genetics
Cilia*
Ciliopathies* / genetics
Humans
Mutation