Chromatin as a metabolic organelle: Integrating the cellular flow of carbon with gene expression

doi:10.1016/j.molcel.2021.12.003

Comment

. 2022 Jan 6;82(1):8-9.

doi: 10.1016/j.molcel.2021.12.003.

Chromatin as a metabolic organelle: Integrating the cellular flow of carbon with gene expression

Chen Cheng¹, Siavash K Kurdistani²

Affiliations

¹ Department of Biological Chemistry, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA.
² Department of Biological Chemistry, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA; Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA; Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA. Electronic address: skurdistani@mednet.ucla.edu.

PMID: 34995510
DOI: 10.1016/j.molcel.2021.12.003

Free article

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Chromatin as a metabolic organelle: Integrating the cellular flow of carbon with gene expression

Chen Cheng et al. Mol Cell. 2022.

Free article

. 2022 Jan 6;82(1):8-9.

doi: 10.1016/j.molcel.2021.12.003.

Authors

Chen Cheng¹, Siavash K Kurdistani²

Affiliations

¹ Department of Biological Chemistry, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA.
² Department of Biological Chemistry, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA; Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA; Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA. Electronic address: skurdistani@mednet.ucla.edu.

PMID: 34995510
DOI: 10.1016/j.molcel.2021.12.003

Abstract

Hsieh et al. (2022) reveal that carbon starvation elicits an unexpected compensatory reallocation of histone acetylation to establish an adaptive gene expression program, demonstrating how chromatin may integrate cellular carbon flow via histone acetylation with gene regulation.

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Glucose starvation induces a switch in the histone acetylome for activation of gluconeogenic and fat metabolism genes.
Hsieh WC, Sutter BM, Ruess H, Barnes SD, Malladi VS, Tu BP. Hsieh WC, et al. Mol Cell. 2022 Jan 6;82(1):60-74.e5. doi: 10.1016/j.molcel.2021.12.015. Mol Cell. 2022. PMID: 34995509 Free PMC article.

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Chromatin as a metabolic organelle: Integrating the cellular flow of carbon with gene expression

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Chromatin as a metabolic organelle: Integrating the cellular flow of carbon with gene expression

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