Chromatin as a metabolic organelle: Integrating the cellular flow of carbon with gene expression

Mol Cell. 2022 Jan 6;82(1):8-9. doi: 10.1016/j.molcel.2021.12.003.


Hsieh et al. (2022) reveal that carbon starvation elicits an unexpected compensatory reallocation of histone acetylation to establish an adaptive gene expression program, demonstrating how chromatin may integrate cellular carbon flow via histone acetylation with gene regulation.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Acetylation
  • Carbon
  • Chromatin* / genetics
  • Gene Expression
  • Histones* / genetics
  • Histones* / metabolism
  • Organelles / metabolism


  • Chromatin
  • Histones
  • Carbon