Abstract
N-substituted 8-carbamoylimidazo[1,2-c]pyrimidines, 9-carbamoylpyrimido[1,2-c]pyrimidines and 8-carbamoyloxazolo[2,3-c]pyrimidines were obtained by the reaction of N-substituted 5-carbamoyl-2-hydroxy-4-mercapto-6-methylpyrimidines with aminoalcohols or ethylene chlorohydrin. Some of the described compounds exhibit weak antiinflammatory and analgetic effects.
MeSH terms
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Animals
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Anti-Inflammatory Agents, Non-Steroidal / chemical synthesis*
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Anti-Inflammatory Agents, Non-Steroidal / toxicity
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Bacteria / drug effects
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Chemical Phenomena
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Chemistry
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Heterocyclic Compounds / chemical synthesis*
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Heterocyclic Compounds / pharmacology
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Heterocyclic Compounds / toxicity
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Imidazoles / chemical synthesis*
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Imidazoles / pharmacology
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Imidazoles / toxicity
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Lethal Dose 50
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Magnetic Resonance Spectroscopy
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Microbial Sensitivity Tests
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Pyrimidines / chemical synthesis*
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Pyrimidines / pharmacology
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Pyrimidines / toxicity
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Rats
Substances
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Anti-Inflammatory Agents, Non-Steroidal
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Heterocyclic Compounds
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Imidazoles
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Pyrimidines