Gene of the month: NKX3.1

J Clin Pathol. 2022 Jun;75(6):361-364. doi: 10.1136/jclinpath-2021-208073. Epub 2022 Jan 7.


NKX3.1 is a multifaceted protein with roles in prostate development and protection from oxidative stress. Acting as a pioneer factor, NKX3.1 interacts with chromatin at enhancers to help integrate androgen regulated signalling. In prostate cancer, NKX3.1 activity is frequently reduced through a combination of mutational and post-translational events. Owing to its specificity for prostate tissue, NKX3.1 has found use as an immunohistochemical marker in routine histopathology practice.

Keywords: immunohistochemistry; prostate; receptors; steroid.

MeSH terms

  • Androgens / metabolism
  • Homeodomain Proteins* / genetics
  • Humans
  • Male
  • Prostatic Neoplasms* / pathology
  • Transcription Factors* / genetics


  • Androgens
  • Homeodomain Proteins
  • NKX3-1 protein, human
  • Transcription Factors