Introduction: We performed a meta-analysis to evaluate the effect of the diet of nitrogen-free analogs of essential amino acids on chronic kidney disease deterioration.
Methods: A systematic literature search up-to September 2021 was done and 14 studies included 1574 subjects with chronic kidney disease at the start of the study; 786 of them had the very low-protein diets supplemented with nitrogen-free analogs and 788 had the conventional low-protein diet.
Results: Very low-protein diet supplemented with nitrogen-free analogs had significantly higher estimated glomerular filtration rate, lower serum creatinine, and lower blood urea nitrogen; however, it had no significant difference in serum albumin, serum cholesterol, serum phosphorous, serum calcium, and parathyroid hormone compared to conventional low-protein diet in subjects with chronic kidney disease.
Conclusion: The very low-protein diets supplemented with nitrogen-free analogs had significantly better kidney functions results compared to the conventional low-protein diets in subjects with chronic kidney disease. Further studies are required to validate these findings.
Keywords: chronic kidney disease; conventional low-protein diet; kidney functions; nitrogen-free analogs; nutrition status.
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