Familial aggregation in noncirrhotic portal fibrosis: a report of four families

Am J Gastroenterol. 1987 Nov;82(11):1130-3.


Noncirrhotic portal fibrosis is a common cause of portal hypertension in India. We report four families with more than one member afflicted with this disorder. Six of the seven (85.5%) patients in whom HLA studies were carried out were HLA-DR 3 positive. The possibility of an immunogenetic basis of noncirrhotic portal fibrosis should be investigated further.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Female
  • HLA Antigens / analysis*
  • HLA-DR Antigens / analysis
  • HLA-DR3 Antigen
  • Humans
  • India
  • Liver Cirrhosis / genetics*
  • Liver Cirrhosis / immunology
  • Male
  • Pedigree


  • HLA Antigens
  • HLA-DR Antigens
  • HLA-DR3 Antigen