An update on principles of m6A targeting

Bing Bai

doi:10.1016/j.tplants.2021.12.007

An update on principles of m⁶A targeting

Trends Plant Sci. 2022 Mar;27(3):224-226. doi: 10.1016/j.tplants.2021.12.007. Epub 2022 Jan 5.

Author

Bing Bai¹

Affiliation

¹ Department of Biology, University of Copenhagen, Ole Maaløes Vej 5, DK-2200 Copenhagen N, Denmark. Electronic address: bing.bai@bio.ku.dk.

PMID: 34998689
DOI: 10.1016/j.tplants.2021.12.007

Abstract

N⁶-methyladenosine (m⁶A) is of fundamental importance in gene regulation. The function of m⁶A is achieved through proteins that recognize m⁶A, known as EVOLUTIONARILY CONSERVED C-TERMINAL REGIONS (ECTs) in arabidopsis (Arabidopsis thaliana). mRNA targets of ECTs and their interaction with m⁶A-containing motifs remain to be revealed. In this forum article, I highlight recent advances in m⁶A targeting.

Keywords: ECT2; HyperTRIBE; iCLIP; m(6)A.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Arabidopsis Proteins* / genetics
Arabidopsis Proteins* / metabolism
Arabidopsis* / metabolism
Intracellular Signaling Peptides and Proteins / metabolism
Protein Binding
RNA, Messenger / genetics

Substances

Arabidopsis Proteins
Intracellular Signaling Peptides and Proteins
RNA, Messenger