The effect of o-salicylate upon pentose phosphate pathway activity in normal and G6PD-deficient red cells

Br J Haematol. 1975 Jun;30(2):225-31. doi: 10.1111/j.1365-2141.1975.tb00536.x.


The effect of the major metabolite of aspirin, namely salicylic acid, upon the pentose phosphate pathway (PPP) of normal and G6PD-deficient red cells has been studied. Salicylic acid was shown to inhibit this pathway in proportion to the amount present. At any concentration of this substance there was greater inhibition of the PPP in G6PD-deficient than in normal red cells.

MeSH terms

  • Blood Glucose / metabolism
  • Erythrocytes / metabolism
  • Glucosephosphate Dehydrogenase Deficiency / blood*
  • Humans
  • Hydrogen-Ion Concentration
  • Methylene Blue
  • Pentosephosphates / antagonists & inhibitors
  • Pentosephosphates / blood
  • Pentosephosphates / metabolism*
  • Sodium Salicylate / metabolism*
  • Sodium Salicylate / pharmacology


  • Blood Glucose
  • Pentosephosphates
  • Methylene Blue
  • Sodium Salicylate