RABEP1/Rabaptin5: a link between autophagy and early endosome homeostasis

Valentina Millarte; Martin Spiess

doi:10.1080/15548627.2021.2021497

RABEP1/Rabaptin5: a link between autophagy and early endosome homeostasis

Autophagy. 2022 Mar;18(3):698-699. doi: 10.1080/15548627.2021.2021497. Epub 2022 Jan 9.

Authors

Valentina Millarte¹, Martin Spiess¹

Affiliation

¹ Biozentrum, University of Basel, Basel, Switzerland.

Abstract

Selective autophagy of damaged organelles assures maintenance of cellular homeostasis in eukaryotes. While the mechanisms by which cells selectively remove dysfunctional mitochondria, lysosomes, endoplasmic reticulum and other organelles has been well characterized, little is known about specific autophagy of damaged early endosomes. In our recent study, we uncovered a new role for RABEP1/Rabaptin5, a long-established regulator of early endosome function, in targeting the autophagy machinery to early endosomes damaged by chloroquine or by internalized Salmonella via interaction with RB1CC1/FIP200 and ATG16L1.

Keywords: ATG16L1; FIP200; Rabaptin5; Salmonella; autophagy; early endosome.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Autophagy*
Autophagy-Related Proteins
Endosomes
Homeostasis
Transport Vesicles*

Substances

Autophagy-Related Proteins

Grants and funding

This work was supported by the Swiss National Science Foundation (grant Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung 31003A-182519).