Three-dimensional structure of interleukin-2

Science. 1987 Dec 18;238(4834):1707-9. doi: 10.1126/science.3500515.

Abstract

Interleukin-2 is an effector protein that participates in modulating the immune response; it has become a focal point for the study of lymphokine structure and function. The three-dimensional structure of the interleukin molecule has been solved to 3.0 angstrom resolution. Interleukin-2 has a novel alpha-helical tertiary structure that suggests one portion of the molecule forms a structural scaffold, which underlies the receptor binding facets of the molecule.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Interleukin-2* / isolation & purification
  • Mice
  • Models, Molecular
  • Protein Conformation
  • Solvents
  • X-Ray Diffraction

Substances

  • Interleukin-2
  • Solvents