Commentary on: Xbp1s-Ddit3, DNA damage and pulmonary hypertension

Clin Sci (Lond). 2022 Jan 14;136(1):163-166. doi: 10.1042/CS20211095.


In this commentary, we discuss new observations stating that spliced X-box-binding protein 1 (Xbp1s)-DNA damage-inducible transcript 3 (Ddit3) promotes monocrotaline (MCT)-induced pulmonary hypertension (Jiang et al., Clinical Science (2021) 135(21), Xbp1s-Ddit3 is involved in the regulation of endoplasmic reticulum stress but is also associated with DNA damage repair machinery. Pathologic DNA damage repair mechanisms have emerged as critical determinants of pulmonary hypertension development. We discuss the potential relationship among Xbp1s-Ddit3, DNA damage, and pulmonary hypertension. Although Xbp1s-Ddit3 contributes to the regulation of cell proliferation and apoptosis and the development of vascular lesions, whether Xbp1s is a friend or foe remains controversial.

Keywords: DNA damage; pulmonary hypertension; xbp1s.

Publication types

  • Comment

MeSH terms

  • Apoptosis
  • DNA Damage
  • Endoplasmic Reticulum Stress / genetics
  • Humans
  • Hypertension, Pulmonary* / chemically induced
  • Hypertension, Pulmonary* / genetics
  • Monocrotaline
  • Transcription Factor CHOP / genetics
  • X-Box Binding Protein 1 / genetics


  • DDIT3 protein, human
  • X-Box Binding Protein 1
  • XBP1 protein, human
  • Transcription Factor CHOP
  • Monocrotaline