99mTc-MDP Bone Scintigraphy and SPECT/CT of Extensive Subcutaneous Calcification in the Setting of Cosmetic-Induced Lipogranulomatosis

Clin Nucl Med. 2022 Feb 1;47(2):e199-e200. doi: 10.1097/RLU.0000000000003966.


A 56-year-old woman with history of cosmetic buttock augmentation via mineral oil injection 20+ years ago presented with extensive abdominopelvic skin induration and hypercalcemia. The 99mTc-MDP bone scintigraphy performed for hypercalcemia revealed marked heterogeneous radiotracer activity partially obscuring the skeleton. Subsequent SPECT/CT demonstrated that the radiotracer activity was associated with exclusively subcutaneous calcification, the extent of which far exceeded the originally augmented gluteal regions. After extensive workup including tissue biopsy, the final diagnosis was subcutaneous calcification and hypercalcemia secondary to cosmetic injection-related sclerosing lipogranulomatosis, which is a very rare complication of cosmetic augmentation.

Publication types

  • Case Reports

MeSH terms

  • Calcinosis*
  • Erdheim-Chester Disease*
  • Female
  • Humans
  • Middle Aged
  • Radiopharmaceuticals
  • Single Photon Emission Computed Tomography Computed Tomography
  • Technetium Tc 99m Medronate


  • Radiopharmaceuticals
  • Technetium Tc 99m Medronate