Association of HMOX-1 rs2071747 with sporadic Parkinson's disease in southern Han Chinese

Abstract

Study objectives: To discover the associations between HMOX-1 and sporadic Parkinson's disease (PD).

Methods: Five hundred sporadic PD patients and 500 healthy controls were recruited in this study. Polymerase chain reaction (PCR) was used.

Results: The dominant model of HMOX-1 rs2071747 was shown statistically significant between PD patients and control after adjustment of age and gender (dominant model: p value: 0.045, OR: 1.51, 95% CI: 1.01-2.27, adjusted). The associations of additive model and dominant model of rs2071747 were also found (additive model: p value: 0.047; dominant model: p value: 0.035, OR: 1.55, 95% CI: 1.03, 2.34).

Conclusions: We found the association of the dominant of HMOX1 rs2071747 with PD. We also found the associations of additive model and dominant model of HMOX1 rs2071747 with late onset PD (LOPD) patients.

Highlights: • The dominant model of HMOX1 rs2071747 was associated with PD. • The additive model of HMOX1 rs2071747 was associated with LOPD. • The dominant model of HMOX1 rs2071747 was associated with LOPD.

Keywords: Genetic associations; HMOX-1; Late onset Parkinson’s disease; Parkinson’s disease; Single nucleotide polymorphism.