Hematology Emergencies in Critically Ill Adults: Benign Hematology

Jenna Spring; Laveena Munshi

doi:10.1016/j.chest.2021.12.650

Hematology Emergencies in Critically Ill Adults: Benign Hematology

Chest. 2022 May;161(5):1285-1296. doi: 10.1016/j.chest.2021.12.650. Epub 2022 Jan 7.

Authors

Jenna Spring¹, Laveena Munshi²

Affiliations

¹ Interdepartmental Division of Critical Care Medicine, Department of Medicine, University of Toronto, Toronto, ON, Canada; Sinai Health System and University Health Network, Toronto, ON, Canada.
² Interdepartmental Division of Critical Care Medicine, Department of Medicine, University of Toronto, Toronto, ON, Canada; Sinai Health System and University Health Network, Toronto, ON, Canada; Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada. Electronic address: Laveena.munshi@sinaihealth.ca.

PMID: 35007552
DOI: 10.1016/j.chest.2021.12.650

Abstract

Hematologic conditions (malignant or benign) may progress to acute critical illness requiring prompt recognition and intensive management. This review outlines diagnostic considerations and approaches to management for intensivists of common benign hematologic emergencies, including the following: thrombotic thrombocytopenic purpura, atypical hemolytic uremic syndrome, disseminated intravascular coagulopathy, catastrophic antiphospholipid antibody syndrome, hemophagocytic lymphohistiocytosis, acute chest syndrome associated with sickle cell disease, and hyperhemolysis syndrome.

Keywords: antiphospholipid syndrome; disseminated intravascular coagulation; hematologic emergencies; hemophagocytic lymphohistiocytosis; thrombotic thrombocytopenic purpura.

Publication types

Review

MeSH terms

Adult
Critical Illness / therapy
Diagnosis, Differential
Emergencies
Hematology*
Humans
Purpura, Thrombotic Thrombocytopenic* / complications
Purpura, Thrombotic Thrombocytopenic* / diagnosis