Natural course and prognosis of HLA-B27-positive oligoarthritis

Clin Rheumatol. 1987 Sep;6 Suppl 2:83-6. doi: 10.1007/BF02203389.


A long-term follow-up of 119 patients with the descriptive diagnosis of B27-positive oligoarthritis showed that after a time between months to several years about half of the patients with this condition develop a definite disease of the seronegative spondarthritis group, especially ankylosing spondylitis. Another great part of the patients go into a complete and presumably persistent remission of their arthritis. After a follow-up time of 8 to 12 years, about 10% present a recurrent B27-associated oligoarthritis with some special clinical features. It is to be discussed whether this condition is a separate disease entity or still an abortive form of a well-known disease of the seronegative spondarthritis group.

MeSH terms

  • Arthritis, Reactive / genetics
  • Arthritis, Rheumatoid / genetics*
  • HLA Antigens / genetics*
  • HLA-B27 Antigen
  • Humans
  • Osteoarthritis / genetics
  • Prognosis
  • Risk Factors
  • Spondylitis, Ankylosing / genetics


  • HLA Antigens
  • HLA-B27 Antigen