Dietary Supplementation with Vitamin D, Fish Oil or Resveratrol Modulates the Gut Microbiome in Inflammatory Bowel Disease

Int J Mol Sci. 2021 Dec 24;23(1):206. doi: 10.3390/ijms23010206.


Gastrointestinal health is influenced by the functional genes and metabolites generated by the human microbiome. As the volume of current biomedical and translational research indicates, the importance and impact of this ecosystem of microorganisms, especially those comprising the gut microbiome on human health, has become increasingly apparent. Changes to the gut microbiome are associated with inflammatory bowel disease (IBD), which is characterized by persistent intestinal inflammation. Furthermore, the lifetime dietary choices of their host may positively or negatively affect both the gut microbiome and its impact on IBD. As such, "anti-inflammatory" dietary supplements, their impact, and mechanisms in restoring gut microbiota homeostasis during IBD is an area of intensive research. Dietary supplementation may represent an important adjuvant treatment avenue for limiting intestinal inflammation in IBD. Overall, this review addresses the development of the gut microbiome, the significance of the gut microbiome in IBD, and the use of dietary supplements such as vitamin D, fish oil, and resveratrol in the mitigation of IBD-associated gut dysbiosis and intestinal inflammation.

Keywords: IBD; dietary supplements; fish oil; gut microbiome; resveratrol; vitamin D.

Publication types

  • Review

MeSH terms

  • Animals
  • Dietary Supplements*
  • Fish Oils / pharmacology
  • Fish Oils / therapeutic use*
  • Gastrointestinal Microbiome* / drug effects
  • Humans
  • Inflammatory Bowel Diseases / drug therapy*
  • Inflammatory Bowel Diseases / microbiology*
  • Inflammatory Bowel Diseases / pathology
  • Resveratrol / pharmacology
  • Resveratrol / therapeutic use*
  • Vitamin D / pharmacology
  • Vitamin D / therapeutic use*


  • Fish Oils
  • Vitamin D
  • Resveratrol