Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Dec 26;14(1):91.
doi: 10.3390/nu14010091.

Effect of Different Types of Intermittent Fasting on Biochemical and Anthropometric Parameters among Patients with Metabolic-Associated Fatty Liver Disease (MAFLD)-A Systematic Review

Gracjan Różański  1 , Derek Pheby  2 , Julia L Newton  3 , Modra Murovska  4 , Paweł Zalewski  1 , Joanna Słomko  1
Affiliations
Free PMC article

Effect of Different Types of Intermittent Fasting on Biochemical and Anthropometric Parameters among Patients with Metabolic-Associated Fatty Liver Disease (MAFLD)-A Systematic Review

Gracjan Różański et al. Nutrients. .
Free PMC article

Abstract

Metabolic-associated fatty liver disease (MAFLD), previously called non-alcoholic fatty liver disease (NAFLD), is the most common chronic liver disease worldwide. It is characterised by excessive fat accumulation in hepatocytes. Currently, no pharmacological therapy is effective for this disease, so non-pharmacological alternatives such as diet, supplementation or physical activity are being sought. For this reason, we reviewed the available databases to analyse the studies conducted to date using different modifications of intermittent fasting among patients with MAFLD. Eight studies using this dietary strategy were included in this review. The results obtained in the different trials are varied and do not allow a clear determination of the effect of the different types of intermittent fasting on anthropometric and biochemical parameters among patients with MAFLD. However, this type of diet seems to show some therapeutic potential, but further studies are needed.

Keywords: MAFLD; diet; intermittent fasting; liver.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
PRISMA flow diagram of the study selection.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Pavlides M., Cobbold J. Non-Alcoholic Fatty Liver Disease. Medicine. 2019;47:728–733. doi: 10.1016/j.mpmed.2019.08.007. - DOI
    1. Younossi Z.M. Non-Alcoholic Fatty Liver Disease—A Global Public Health Perspective. J. Hepatol. 2019;70:531–544. doi: 10.1016/j.jhep.2018.10.033. - DOI - PubMed
    1. Williams C.D., Stengel J., Asike M.I., Torres D.M., Shaw J., Contreras M., Landt C.L., Harrison S.A. Prevalence of Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis among a Largely Middle-Aged Population Utilizing Ultrasound and Liver Biopsy: A Prospective Study. Gastroenterology. 2011;140:124–131. doi: 10.1053/j.gastro.2010.09.038. - DOI - PubMed
    1. Słomko J., Zalewska M., Niemiro W., Kujawski S., Słupski M., Januszko-Giergielewicz B., Zawadka-Kunikowska M., Newton J., Hodges L., Kubica J., et al. Evidence-Based Aerobic Exercise Training in Metabolic-Associated Fatty Liver Disease: Systematic Review with Meta-Analysis. J. Clin. Med. 2021;10:1659. doi: 10.3390/jcm10081659. - DOI - PMC - PubMed
    1. Welsh J.A., Karpen S., Vos M.B. Increasing Prevalence of Nonalcoholic Fatty Liver Disease Among United States Adolescents, 1988–1994 to 2007–2010. J. Pediatr. 2013;162:496–500. doi: 10.1016/j.jpeds.2012.08.043. - DOI - PMC - PubMed

Publication types