New Promising Therapeutic Avenues of Curcumin in Brain Diseases

Molecules. 2021 Dec 31;27(1):236. doi: 10.3390/molecules27010236.


Curcumin, the dietary polyphenol isolated from Curcuma longa (turmeric), is commonly used as an herb and spice worldwide. Because of its bio-pharmacological effects curcumin is also called "spice of life", in fact it is recognized that curcumin possesses important proprieties such as anti-oxidant, anti-inflammatory, anti-microbial, antiproliferative, anti-tumoral, and anti-aging. Neurodegenerative diseases such as Alzheimer's Diseases, Parkinson's Diseases, and Multiple Sclerosis are a group of diseases characterized by a progressive loss of brain structure and function due to neuronal death; at present there is no effective treatment to cure these diseases. The protective effect of curcumin against some neurodegenerative diseases has been proven by in vivo and in vitro studies. The current review highlights the latest findings on the neuroprotective effects of curcumin, its bioavailability, its mechanism of action and its possible application for the prevention or treatment of neurodegenerative disorders.

Keywords: Alzheimer’s diseases; Parkinson’s diseases; anti-inflammatory; curcumin; epilepsy; glioblastoma multiforme; multiple sclerosis; natural flavonoid; neurodegenerative diseases; neuroinflammation.

Publication types

  • Review

MeSH terms

  • Animals
  • Anti-Inflammatory Agents / pharmacology
  • Anti-Inflammatory Agents / therapeutic use
  • Antineoplastic Agents, Phytogenic / pharmacology
  • Antineoplastic Agents, Phytogenic / therapeutic use
  • Antioxidants / pharmacology
  • Antioxidants / therapeutic use
  • Biomarkers
  • Brain Diseases / diagnosis
  • Brain Diseases / drug therapy*
  • Brain Diseases / etiology
  • Curcumin / chemistry
  • Curcumin / pharmacology*
  • Curcumin / therapeutic use*
  • Diagnosis, Differential
  • Disease Management
  • Disease Susceptibility
  • Humans
  • Treatment Outcome


  • Anti-Inflammatory Agents
  • Antineoplastic Agents, Phytogenic
  • Antioxidants
  • Biomarkers
  • Curcumin