Vitamin E enriched diet increases the rate of orthodontic tooth movement

Am J Orthod Dentofacial Orthop. 2022 May;161(5):687-697.e3. doi: 10.1016/j.ajodo.2020.10.033. Epub 2022 Jan 7.


Introduction: Vitamin E is a popular antioxidant suggested to affect bone turnover. However, the effects of a vitamin E enriched diet on the rate of tooth movement are unknown. Therefore, this study aimed to evaluate tooth movement in rats receiving a vitamin E enriched diet. In addition, we examined bone remodeling in experimental and control rats.

Methods: Thirty-two 6-week-old male rats were divided into 4 groups: (1) group 1 (n = 8): orthodontic tooth movement (OTM) for 4 days + regular diet; (2) group 2 (n = 8): OTM for 14 days + regular diet; (3) group 3 (n = 8): OTM for 4 days + vitamin E diet; and (4) group 4 (n = 8) - OTM for 14 days + vitamin E diet. Maxillary alveolar bones and femurs of rats were analyzed by microcomputed tomography and histology.

Results: Rats fed a vitamin E diet presented an increased OTM rate at days 4 and 14. We found an increased number of osteoclasts and decreased bone volume in the vitamin E diet group at day 14 of OTM. In addition, there was increased expression of the microphthalmia-associated transcription factor in the alveolar bone of the vitamin E diet group. In contrast, there was no difference in bone remodeling in femurs or alveolar bone at the control side.

Conclusions: We found that an enriched vitamin E diet increases the rate of OTM in rats, suggesting that vitamin E may be useful as an avenue to accelerate OTM.

MeSH terms

  • Animals
  • Bone Remodeling
  • Diet
  • Humans
  • Male
  • Maxilla
  • Osteoclasts
  • Rats
  • Tooth Movement Techniques*
  • Vitamin E* / pharmacology
  • X-Ray Microtomography


  • Vitamin E