Metabolic and lifestyle factors in relation to senile cataract: a Mendelian randomization study

Sci Rep. 2022 Jan 10;12(1):409. doi: 10.1038/s41598-021-04515-x.

Abstract

We conducted a Mendelian randomization study to determine the associations of body mass index (BMI), type 2 diabetes (T2D), systolic blood pressure (SBP), coffee and alcohol consumption and smoking initiation with senile cataract. Independent single nucleotide polymorphisms associated with the metabolic and lifestyle factors at the p < 5 × 10-8 were selected as instrument variables. Summary-level data for senile cataract were obtained from the FinnGen consortium (20,157 cases and 154,905 non-cases) and UK Biobank study (6332 cases and 354,862 non-cases). Higher genetically predicted BMI and SBP and genetic predisposition to T2D and smoking initiation were associated with an increased risk of senile cataract. The combined odds ratios were 1.19 (95% confidence interval (CI) 1.09-1.29; p < 0.001) per one standard deviation increase in BMI (~ 4.8 kg/m2), 1.13 (95% CI 1.04-1.23; p = 0.004) per 10 mmHg increase in SBP, 1.06 (95% CI 1.03-1.09; p < 0.001) per one unit increase in log-transformed odds ratio of T2D, and 1.19 (95% CI 1.10-1.29; p < 0.001) per one standard deviation increase in prevalence of smoking initiation. Genetically predicted coffee consumption showed a suggestive association with senile cataract (odds ratio per 50% increase, 1.18, 95% CI 1.00-1.40; p = 0.050). This study suggests causal roles of obesity, T2D, SBP and smoking in senile cataract.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Age Factors
  • Alcohol Drinking / adverse effects
  • Alcohol Drinking / epidemiology
  • Alcohol Drinking / genetics
  • Blood Pressure / genetics
  • Body Mass Index
  • Case-Control Studies
  • Cataract / diagnosis
  • Cataract / epidemiology
  • Cataract / genetics*
  • Coffee / adverse effects
  • Diabetes Mellitus, Type 2 / diagnosis
  • Diabetes Mellitus, Type 2 / epidemiology
  • Diabetes Mellitus, Type 2 / genetics*
  • Female
  • Genetic Predisposition to Disease
  • Humans
  • Hypertension / diagnosis
  • Hypertension / epidemiology
  • Hypertension / genetics*
  • Life Style*
  • Male
  • Mendelian Randomization Analysis
  • Obesity / diagnosis
  • Obesity / epidemiology
  • Obesity / genetics*
  • Phenotype
  • Polymorphism, Single Nucleotide*
  • Prevalence
  • Risk Assessment
  • Risk Factors
  • Smoking / adverse effects
  • Smoking / epidemiology
  • Smoking / genetics

Substances

  • Coffee