Background: To systematically evaluate the clinical efficacy of Jinfeng pill in the treatment of patients with thin endometrial infertility.
Methods: The databases of PubMed, Embase, Cochrane Library, Chinese National Knowledge Infrastructure (CNKI), Chinese Scientific Journal Database (VIP), Wanfang Science and Technology Journal Full-text Database, and Chinese Biomedical Literature Database (CBM) were used to search for articles related to Jinfeng pills in the treatment of thin endometrial infertility from database establishment to September 2021. Duplicate articles were eliminated through Endnote X9 software. Data were recorded using Stata 15.1 software, and a meta-analysis of the results was performed using fixed or random-effects models for pregnancy rate, abortion rate, endometrial thickness, and endometrial morphology type A. A funnel plot was used to evaluate the publication bias of the included literature. Article heterogeneity was judged by the I2 test, suggesting clear heterogeneity when I2>50%, and sensitivity analysis by excluding studies when the heterogeneity was too high.
Results: Finally, 3 articles were included. Meta-analysis showed that the pregnancy rate in the trial group was significantly higher than that in the control group; the abortion rate in the trial group was significantly lower than that in the control group; the endometrial thickening in the trial group was significantly greater than that in the control group, the above three results were statistically different. Regarding the issue of endometrial type, the results showed that there was no significant difference between the 2 groups, and the difference was not statistically significant. The funnel plot results of pregnancy rate showed that the scatter was asymmetric, suggesting that there may have been publication bias.
Discussion: Jinfeng pill can effectively improve the clinical symptoms of thin endometrial infertility, improve the pregnancy rate, reduce the abortion rate, and improve endometrial thickness, However, due to the small number of included articles and the quality of included studies, our conclusion requires verification through a larger sample and a higher quality clinical study.
Keywords: Jinfeng pill; infertility; meta-analysis; thin endometrium.