Exercise as a Moderator of Persistent Neuroendocrine Symptoms of COVID-19

Exerc Sport Sci Rev. 2022 Apr 1;50(2):65-72. doi: 10.1249/JES.0000000000000284.


Precipitated by chronic psychological stress, immune system dysregulation, and a hyperinflammatory state, the sequelae of postacute COVID-19 (long COVID) include depression and new-onset diabetes. We hypothesize that exercise counters the neuropsychiatric and endocrine sequelae of long COVID by inducing the release of circulating factors that mediate the anti-inflammatory response, support brain homeostasis, and increase insulin sensitivity.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Brain
  • COVID-19* / complications
  • Disease Progression
  • Exercise
  • Humans
  • Post-Acute COVID-19 Syndrome