Exercise as a Moderator of Persistent Neuroendocrine Symptoms of COVID-19

Candida J Rebello; Christopher L Axelrod; Charles F Reynolds 3rd; Frank L Greenway; John P Kirwan

doi:10.1249/JES.0000000000000284

Exercise as a Moderator of Persistent Neuroendocrine Symptoms of COVID-19

Exerc Sport Sci Rev. 2022 Apr 1;50(2):65-72. doi: 10.1249/JES.0000000000000284.

Authors

Candida J Rebello¹, Christopher L Axelrod¹, Charles F Reynolds 3rd², Frank L Greenway¹, John P Kirwan¹

Affiliations

¹ Pennington Biomedical Research Center, Baton Rouge, LA.
² University of Pittsburgh School of Medicine, Pittsburg, PA.

Abstract

Precipitated by chronic psychological stress, immune system dysregulation, and a hyperinflammatory state, the sequelae of postacute COVID-19 (long COVID) include depression and new-onset diabetes. We hypothesize that exercise counters the neuropsychiatric and endocrine sequelae of long COVID by inducing the release of circulating factors that mediate the anti-inflammatory response, support brain homeostasis, and increase insulin sensitivity.

Publication types

Research Support, N.I.H., Extramural

MeSH terms

Brain
COVID-19* / complications
Disease Progression
Exercise
Humans
Post-Acute COVID-19 Syndrome

Abstract

Publication types

MeSH terms

Grants and funding