Maternal inflammation is hard for offspring to stomach

Immunity. 2022 Jan 11;55(1):6-8. doi: 10.1016/j.immuni.2021.12.005.


Individuals with neurodevelopmental disorders often experience comorbid gastrointestinal distress and dysregulated immune responses, yet the underlying mechanisms remain unclear. In this issue of Immunity, Kim et al. utilize a murine maternal immune activation model of autism and find that inflammation can alter the microbiota of mothers, which postnatally primes offspring CD4+ T cells and increases susceptibility to intestinal inflammation.

Publication types

  • Comment

MeSH terms

  • Animals
  • Gastrointestinal Microbiome*
  • Humans
  • Inflammation
  • Mice
  • Microbiota*
  • Prenatal Exposure Delayed Effects*
  • Stomach