Developing Treatments for Alzheimer's and Related Disorders with Precision Medicine: A Vision

Dimitrios Avramopoulos; Dimitrios Kapogiannis; Jeannie-Marie Leoutsakos; Constantine G Lyketsos; Vasiliki Mahairaki; Milap Nowrangi; Kenichi Oishi; Esther S Oh; Paul B Rosenberg; Quincy Samus; Gwenn S Smith; Kenneth Witwer; Sevil Yasar; Peter P Zandi

doi:10.1007/978-3-030-78787-5_49

Developing Treatments for Alzheimer's and Related Disorders with Precision Medicine: A Vision

Adv Exp Med Biol. 2021:1339:395-402. doi: 10.1007/978-3-030-78787-5_49.

Authors

Affiliations

¹ Department of Genetic Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
² Department of Neurology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
³ Intramural Research Program, National Institute on Aging (NIA/NIH), Baltimore, MD, USA.
⁴ Departments of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
⁵ Departments of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins University, Baltimore, MD, USA. kostas@jhmi.edu.
⁶ Departments of Radiology and Radiological Sciences, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
⁷ Departments of Medicine (Geriatric Medicine and Gerontology), School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
⁸ Departments of Molecular and Comparative Pathobiology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.

Abstract

Precision medicine, also known as personalized medicine, is concerned with finding the right treatment for the right patient at the right time. It is a way of thinking focused on parsing heterogeneity ultimately down to the level of the individual. Its main mission is to identify characteristics of heterogeneous clinical conditions so as to target tailored therapies to individuals. Precision Medicine however is not an agnostic collection of all manner of clinical, genetic and other biologic data in select cohorts. This is an important point. Simply collecting as much information as possible on individuals without applying this way of thinking should not be considered Precision Medicine.

Keywords: Alzheimer’s; Precision medicine treatments.

MeSH terms

Alzheimer Disease* / diagnosis
Alzheimer Disease* / drug therapy
Alzheimer Disease* / genetics
Humans
Precision Medicine*

Abstract

MeSH terms

Grants and funding