Inactivity Causes Resistance to Improvements in Metabolism After Exercise

Exerc Sport Sci Rev. 2022 Apr 1;50(2):81-88. doi: 10.1249/JES.0000000000000280.


Prolonged sitting prevents a 1-h bout of running from improving fat oxidation and reducing plasma triglycerides. This "exercise resistance" can be prevented by taking 8500 steps·d-1 or by interrupting 8 h of sitting with hourly cycle sprints. We hypothesize that there is an interplay between background physical activity (e.g., steps·d-1) and the exercise stimuli in regulating some acute and chronic adaptations to exercise.

MeSH terms

  • Exercise / physiology
  • Humans
  • Postprandial Period* / physiology
  • Running*
  • Sedentary Behavior
  • Triglycerides / metabolism


  • Triglycerides