Microbial Cgr2 will let your Th17 cells ROR(γT)

Naomi Rodriguez-Marino; Luisa Cervantes-Barragan

doi:10.1016/j.chom.2021.12.014

Microbial Cgr2 will let your Th17 cells ROR(γT)

Cell Host Microbe. 2022 Jan 12;30(1):10-12. doi: 10.1016/j.chom.2021.12.014.

Authors

Naomi Rodriguez-Marino¹, Luisa Cervantes-Barragan²

Affiliations

¹ Department of Microbiology and Immunology, Emory University, Atlanta, GA, USA.
² Department of Microbiology and Immunology, Emory University, Atlanta, GA, USA. Electronic address: lcervantes@emory.edu.

PMID: 35026131
DOI: 10.1016/j.chom.2021.12.014

Abstract

In this issue of Cell Host & Microbe, Alexander et al. show that the enzyme cardiac glycoside reductase 2 (cgr2), which is produced by Eggerthella lenta, metabolizes RORγT inhibitors, resulting in an increased Th17 response and more severe inflammation in colitis models. The effect of cgr2 can be neutralized by a diet rich in arginine.

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MeSH terms

Colitis*
Humans
Nuclear Receptor Subfamily 1, Group F, Member 3* / genetics
Oxidoreductases
Th17 Cells

Substances

Nuclear Receptor Subfamily 1, Group F, Member 3
Oxidoreductases