Trend in sensitivity of SARS-CoV-2 serology one year after mild and asymptomatic COVID-19: unpacking potential bias in seroprevalence studies

Clin Infect Dis. 2022 Jan 13;ciac020. doi: 10.1093/cid/ciac020. Online ahead of print.

Abstract

A key aim of serosurveillance during the COVID-19 pandemic has been to estimate the prevalence of prior infection, by correcting crude seroprevalence against estimated test performance for PCR-confirmed COVID-19. We show that poor generalisability of sensitivity estimates to some target populations may lead to substantial underestimation of case numbers.

Keywords: COVID-19; antibody; sensitivity; serology; surveillance.