Clinical features and outcomes of coronavirus disease 2019 in early infants in Japan: A case series and literature review

J Infect Chemother. 2022 Apr;28(4):582-586. doi: 10.1016/j.jiac.2021.12.026. Epub 2022 Jan 6.


The clinical picture in early infants with COVID-19 has been described in a limited number of reports, mainly from European countries, United States, and China, but not Japan. Although several reports suggested that early infants can develop more severe COVID-19 disease than older children, risk factors for severe illness and differences according to nationality or ethnicity remain unclear. We report a case series of 13 infants ≤90 days old with COVID-19 in Japan. All patients had mild outcomes and did not require respiratory support or intensive care.

Keywords: COVID-19; Infant; Neonate; SARS-CoV-2.

Publication types

  • Review

MeSH terms

  • Adolescent
  • COVID-19*
  • Child
  • Critical Care
  • Humans
  • Infant
  • Japan / epidemiology
  • Risk Factors
  • SARS-CoV-2
  • United States