Caught in a trap: How pre-clinical studies in laboratory mice exaggerate vaccine responses

Cell Rep Med. 2021 Dec 21;2(12):100484. doi: 10.1016/j.xcrm.2021.100484.

Abstract

In a recent issue of Cell Host and Microbe, Fiege and colleagues1 report that laboratory mice exposed to pathogens from pet-store mice exhibit impaired humoral immunity to influenza vaccination and display gene expression signatures that more authentically reflect human vaccine responses.

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