Severe neonatal hypercalcemia revealing congenital mesoblastic nephroma: A case report and management of neonatal hypercalcemia: Severe neonatal hypercalcemia revealing congenital mesoblastic nephroma

Arch Pediatr. 2022 Feb;29(2):153-156. doi: 10.1016/j.arcped.2021.11.013. Epub 2022 Jan 14.


Congenital mesoblastic nephroma is a rare pediatric renal tumor and has been reported in patients presenting with palpable abdominal mass, arterial hypertension, hematuria, polyuria, or hypercalcemia. Here we present the case of a 1-month-old neonate with suspected parathyroid hormone (PTH)-related peptide (PTH-rp)-mediated severe hypercalcemia revealing congenital mesoblastic nephroma. Preoperatively, hypercalcemia was corrected with hydration, furosemide, pamidronate, and low-calcium infant formula. Unilateral nephrectomy led to the resolution of hypercalcemia, transient hyperparathyroidism, and transient vitamin D and mineral supplementation. We conclude that congenital mesoblastic nephroma can secrete PTH-rp that can cause severe hypercalcemia.

Keywords: Congenital mesoblastic nephroma; Hypercalcemia; Hypercalcemia management; PTH-rp; Pediatrics.

Publication types

  • Case Reports

MeSH terms

  • Calcium / blood
  • Female
  • Food, Fortified
  • Furosemide / therapeutic use
  • Humans
  • Hypercalcemia / congenital*
  • Hypercalcemia / etiology
  • Hypercalcemia / therapy
  • Hypertension
  • Infant Formula
  • Infant, Newborn
  • Kidney Neoplasms / complications
  • Kidney Neoplasms / congenital*
  • Kidney Neoplasms / surgery
  • Nephrectomy
  • Nephroma, Mesoblastic / complications
  • Nephroma, Mesoblastic / congenital*
  • Nephroma, Mesoblastic / surgery
  • Pamidronate / therapeutic use
  • Treatment Outcome


  • Furosemide
  • Pamidronate
  • Calcium