Chemo-immunotherapy for unresectable bronchogenic carcinoma

Cancer Treat Rep. 1978 May;62(5):681-7.


Seventy-nine patients with metastatic or unresectable bronchogenic carcinoma were treated with a regimen of combination chemotherapy which included methotrexate, Oncovin (vincristine), cyclophosphamide, and adriamycin (MOCA), and were randomized to receive no additional therapy, immunotherapy with bacillus Calmette-Guérin, or immunotherapy with Corynebacterium parvum (C. parvum). The response rate and estimated median survival time were 68% and 42 weeks in small cell carcinoma and 18% and 29 weeks in other histologic types. Improved survival correlated with high performance status and response to therapy. Immunotherapy did not improve response, time to progression, or hematopoietic tolerance of chemotherapy. C. parvum was associated with significant morbidity and was poorly tolerated. MOCA appears to be of modest value in the treatment of bronchogenic carcinoma, particularly of the small cell type. A role for immunotherapy remains unproven.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • BCG Vaccine / adverse effects
  • BCG Vaccine / therapeutic use
  • Bacterial Vaccines / adverse effects
  • Bacterial Vaccines / therapeutic use
  • Carcinoma, Bronchogenic / drug therapy
  • Carcinoma, Bronchogenic / therapy*
  • Clinical Trials as Topic
  • Cyclophosphamide / therapeutic use
  • Doxorubicin / therapeutic use
  • Drug Therapy, Combination / adverse effects
  • Humans
  • Lung Neoplasms / drug therapy
  • Lung Neoplasms / therapy*
  • Methotrexate / therapeutic use
  • Middle Aged
  • Propionibacterium acnes / immunology
  • Vincristine / therapeutic use


  • BCG Vaccine
  • Bacterial Vaccines
  • Vincristine
  • Doxorubicin
  • Cyclophosphamide
  • Methotrexate